The nuclear transport receptor Importin-11 is a tumor suppressor that maintains PTEN protein

Phosphatase and tensin homologue (PTEN) protein levels are critical for tumor suppression. However, the search for a recurrent cancer-associated gene alteration that causes PTEN degradation has remained futile. In this study, we show that Importin-11 (Ipo11) is a transport receptor for PTEN that is...

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發表在:J Cell Biol
Main Authors: Chen, Muhan, Nowak, Dawid G., Narula, Navneet, Robinson, Brian, Watrud, Kaitlin, Ambrico, Alexandra, Herzka, Tali M., Zeeman, Martha E., Minderer, Matthias, Zheng, Wu, Ebbesen, Saya H., Plafker, Kendra S., Stahlhut, Carlos, Wang, Victoria M.Y., Wills, Lorna, Nasar, Abu, Castillo-Martin, Mireia, Cordon-Cardo, Carlos, Wilkinson, John E., Powers, Scott, Sordella, Raffaella, Altorki, Nasser K., Mittal, Vivek, Stiles, Brendon M., Plafker, Scott M., Trotman, Lloyd C.
格式: Artigo
語言:Inglês
出版: The Rockefeller University Press 2017
主題:
Research Articles
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC5350510/
https://ncbi.nlm.nih.gov/pubmed/28193700
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201604025
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