Identification of PHLPP1 as a tumor suppressor reveals the role of feedback activation in PTEN-mutant prostate cancer progression

Hyper-activation of the PI 3-Kinase/AKT pathway is a driving force of many cancers. Here we identify the AKT-inactivating phosphatase PHLPP1 as a prostate tumor suppressor. We show that Phlpp1-loss causes neoplasia and, upon partial Pten-loss, carcinoma in mouse prostate. This genetic setting initia...

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Detalhes bibliográficos
Main Authors: Chen, Muhan, Pratt, Christopher P., Zeeman, Martha E., Schultz, Nikolaus, Taylor, Barry S., O’Neill, Audrey, Castillo-Martin, Mireia, Nowak, Dawid G., Naguib, Adam, Grace, Danielle M., Murn, Jernej, Navin, Nick, Atwal, Gurinder S., Sander, Chris, Gerald, William L., Cordon-Cardo, Carlos, Newton, Alexandra C., Carver, Brett S., Trotman, Lloyd C.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3176728/
https://ncbi.nlm.nih.gov/pubmed/21840483
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccr.2011.07.013
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