RapidCaP, a novel GEM model for analysis and therapy of metastatic prostate cancer reveals Myc as a driver of Pten-mutant metastasis

Genetically Engineered Mouse (GEM) models are a pillar of functional cancer research. Here we developed RapidCaP, a GEM modeling system that uses surgical injection for viral gene delivery to prostate. We show that in Pten-deficiency, loss of p53 suffices to trigger metastasis to distant sites at gr...

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Bibliographische Detailangaben
Hauptverfasser: Cho, Hyejin, Herzka, Tali, Zheng, Wu, Qi, Jun, Wilkinson, John E., Bradner, James E., Robinson, Brian D., Castillo-Martin, Mireia, Cordon-Cardo, Carlos, Trotman, Lloyd C.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2014
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4084646/
https://ncbi.nlm.nih.gov/pubmed/24444712
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-13-0346
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