Pten Dose Dictates Cancer Progression in the Prostate

Complete inactivation of the PTEN tumor suppressor gene is extremely common in advanced cancer, including prostate cancer (CaP). However, one PTEN allele is already lost in the vast majority of CaPs at presentation. To determine the consequence of PTEN dose variations on cancer progression, we have...

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Détails bibliographiques
Auteurs principaux: Trotman, Lloyd C, Niki, Masaru, Dotan, Zohar A, Koutcher, Jason A, Di Cristofano, Antonio, Xiao, Andrew, Khoo, Alan S, Roy-Burman, Pradip, Greenberg, Norman M, Dyke, Terry Van, Cordon-Cardo, Carlos, Pandolfi, Pier Paolo
Format: Artigo
Langue:Inglês
Publié: Public Library of Science 2003
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC270016/
https://ncbi.nlm.nih.gov/pubmed/14691534
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.0000059
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