Pten Dose Dictates Cancer Progression in the Prostate

Complete inactivation of the PTEN tumor suppressor gene is extremely common in advanced cancer, including prostate cancer (CaP). However, one PTEN allele is already lost in the vast majority of CaPs at presentation. To determine the consequence of PTEN dose variations on cancer progression, we have...

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Detalhes bibliográficos
Main Authors: Trotman, Lloyd C, Niki, Masaru, Dotan, Zohar A, Koutcher, Jason A, Di Cristofano, Antonio, Xiao, Andrew, Khoo, Alan S, Roy-Burman, Pradip, Greenberg, Norman M, Dyke, Terry Van, Cordon-Cardo, Carlos, Pandolfi, Pier Paolo
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2003
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC270016/
https://ncbi.nlm.nih.gov/pubmed/14691534
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.0000059
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