Crucial role of p53-dependent cellular senescence in suppression of Pten-deficient tumorigenesis

Cellular senescence has been theorized to oppose neoplastic transformation triggered by activation of oncogenic pathways in vitro1–3, but the relevance of senescence in vivo has not been established. The PTEN and p53 tumour suppressors are among the most commonly inactivated or mutated genes in huma...

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Hlavní autoři: Chen, Zhenbang, Trotman, Lloyd C., Shaffer, David, Lin, Hui-Kuan, Dotan, Zohar A., Niki, Masaru, Koutcher, Jason A., Scher, Howard I., Ludwig, Thomas, Gerald, William, Cordon-Cardo, Carlos, Pandolfi, Pier Paolo
Médium: Artigo
Jazyk:Inglês
Vydáno: 2005
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1939938/
https://ncbi.nlm.nih.gov/pubmed/16079851
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature03918
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