Crucial role of p53-dependent cellular senescence in suppression of Pten-deficient tumorigenesis

Cellular senescence has been theorized to oppose neoplastic transformation triggered by activation of oncogenic pathways in vitro1–3, but the relevance of senescence in vivo has not been established. The PTEN and p53 tumour suppressors are among the most commonly inactivated or mutated genes in huma...

Popoln opis

Shranjeno v:
Bibliografske podrobnosti
Main Authors: Chen, Zhenbang, Trotman, Lloyd C., Shaffer, David, Lin, Hui-Kuan, Dotan, Zohar A., Niki, Masaru, Koutcher, Jason A., Scher, Howard I., Ludwig, Thomas, Gerald, William, Cordon-Cardo, Carlos, Pandolfi, Pier Paolo
Format: Artigo
Jezik:Inglês
Izdano: 2005
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC1939938/
https://ncbi.nlm.nih.gov/pubmed/16079851
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature03918
Oznake: Označite
Brez oznak, prvi označite!

Podobne knjige/članki