Pleckstrin homology domain leucine-rich repeat protein phosphatases set the amplitude of receptor tyrosine kinase output

Growth factor receptor levels are aberrantly high in diverse cancers, driving the proliferation and survival of tumor cells. Understanding the molecular basis for this aberrant elevation has profound clinical implications. Here we show that the pleckstrin homology domain leucine-rich repeat protein...

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Detalhes bibliográficos
Main Authors: Reyes, Gloria, Niederst, Matt, Cohen-Katsenelson, Ksenya, Stender, Joshua D., Kunkel, Maya T., Chen, Muhan, Brognard, John, Sierecki, Emma, Gao, Tianyan, Nowak, Dawid G., Trotman, Lloyd C., Glass, Christopher K., Newton, Alexandra C.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2014
Assuntos:
PNAS Plus
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4183331/
https://ncbi.nlm.nih.gov/pubmed/25201979
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1404221111
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