Pleckstrin Homology Domain Leucine-rich Repeat Protein Phosphatase (PHLPP): A New Player in Cell Signaling

Precise balance between phosphorylation, catalyzed by protein kinases, and dephosphorylation, catalyzed by protein phosphatases, is essential for cellular homeostasis. Deregulation of this balance leads to pathophysiological states that drive diseases such as cancer, heart disease, and diabetes. The...

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Bibliographic Details
Main Authors: Warfel, Noel A., Newton, Alexandra C.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2012
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3281723/
https://ncbi.nlm.nih.gov/pubmed/22144674
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.R111.318675
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