Pharmacological Inhibition of Pleckstrin Homology Domain Leucine-Rich Repeat Protein Phosphatase Is Neuroprotective: Differential Effects on Astrocytes

Pleckstrin homology domain and leucine-rich repeat protein phosphatase 1 (PHLPP1) inhibits protein kinase B (AKT) survival signaling in neurons. Small molecule pan-PHLPP inhibitors (selective for PHLPP1 and PHLPP2) may offer a translatable method to induce AKT neuroprotection. We tested several rece...

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Autori principali: Jackson, Travis C., Verrier, Jonathan D., Drabek, Tomas, Janesko-Feldman, Keri, Gillespie, Delbert G., Uray, Thomas, Dezfulian, Cameron, Clark, Robert S., Bayir, Hülya, Jackson, Edwin K., Kochanek, Patrick M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: The American Society for Pharmacology and Experimental Therapeutics 2013
Soggetti:
Neuropharmacology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3807060/
https://ncbi.nlm.nih.gov/pubmed/24023368
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.113.206888
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