Discovery of Small Molecule Inhibitors of the PH Domain Leucine-Rich Repeat Protein Phosphatase (PHLPP) by Chemical and Virtual Screening

[Image: see text] PH domain Leucine-rich repeat protein phosphatase (PHLPP) directly dephosphorylates and inactivates Akt and protein kinase C, poising it as a prime target for pharmacological intervention of two major survival pathways. Here we report on the discovery of small molecule inhibitors o...

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Bibliographic Details
Main Authors: Sierecki, Emma, Sinko, William, McCammon, J. Andrew, Newton, Alexandra C.
Format: Artigo
Language:Inglês
Published: American Chemical Society 2010
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2951065/
https://ncbi.nlm.nih.gov/pubmed/20836557
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm100331d
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