Deletion of the PH-domain and Leucine-rich Repeat Protein Phosphatase 1 (Phlpp1) Increases Fibroblast Growth Factor (Fgf) 18 Expression and Promotes Chondrocyte Proliferation

Endochondral ossification orchestrates formation of the vertebrate skeleton and is often induced during disease and repair processes of the musculoskeletal system. Here we show that the protein phosphatase Phlpp1 regulates endochondral ossification. Phlpp1 null mice exhibit decreased bone mass and n...

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Pubblicato in:J Biol Chem
Autori principali: Bradley, Elizabeth W., Carpio, Lomeli R., Newton, Alexandra C., Westendorf, Jennifer J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2015
Soggetti:
Molecular Bases of Disease
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4481226/
https://ncbi.nlm.nih.gov/pubmed/25953896
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.612937
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