Histone Deacetylase 3 Suppression Increases PH Domain and Leucine-rich Repeat Phosphatase (Phlpp)1 Expression in Chondrocytes to Suppress Akt Signaling and Matrix Secretion

HDACs epigenetically regulate cellular processes by modifying chromatin and influencing gene expression. We previously reported that conditional deletion of Hdac3 in osteo-chondroprogenitor cells with Osx1-Cre caused severe osteopenia due to abnormal maturation of osteoblasts. The mice were also sma...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Bradley, Elizabeth W., Carpio, Lomeli R., Westendorf, Jennifer J.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Society for Biochemistry and Molecular Biology 2013
Gaiak:
Signal Transduction
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC3617261/
https://ncbi.nlm.nih.gov/pubmed/23408427
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.423723
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