Transcriptional Regulation in Prostate Cancer

Por Labbé, David P., Brown, Myles
Publicado no Cold Spring Harb Perspect Med (2018)

Prostate cancer genetic-susceptibility locus on chromosome 20q13 is androgen receptor-regulated and amplified in metastatic tumors

Por Labbé, David P., Nowak, Dawid G., Deblois, Geneviève, Lessard, Laurent, Giguère, Vincent, Trotman, Lloyd C., Tremblay, Michel L.
Publicado em 2013

Evidence that EZH2 Deregulation is an Actionable Therapeutic Target for Prevention of Prostate Cancer

Por Burkhart, Deborah L., Morel, Katherine L., Wadosky, Kristine M., Labbé, David P., Galbo, Phillip M., Dalimov, Zafardjan, Xu, Bo, Loda, Massimo, Ellis, Leigh
Publicado no Cancer Prev Res (Phila) (2020)

PTP1B is an androgen receptor-regulated phosphatase associated with tumor-promoting functions in prostate cancer

Por Lessard, Laurent, Labbé, David P., Deblois, Geneviève, Bégin, Louis R., Hardy, Serge, Mes-Masson, Anne-Marie, Saad, Fred, Trotman, Lloyd, Giguère, Vincent, Tremblay, Michel L.
Publicado no Cancer Res (2012)

PTP1B deficiency enables the ability of a high fat diet to drive the invasive character of PTEN-deficient prostate cancers

Por Labbé, David P., Uetani, Noriko, Vinette, Valérie, Lessard, Laurent, Aubry, Isabelle, Migon, Eva, Sirois, Jacinthe, Haigh, Jody J., Bégin, Louis R., Trotman, Lloyd C., Paquet, Marilène, Tremblay, Michel L.
Publicado no Cancer Res (2016)

ERRα mediates metabolic adaptations driving lapatinib resistance in breast cancer

Por Deblois, Geneviève, Smith, Harvey W., Tam, Ingrid S., Gravel, Simon-Pierre, Caron, Maxime, Savage, Paul, Labbé, David P., Bégin, Louis R., Tremblay, Michel L., Park, Morag, Bourque, Guillaume, St-Pierre, Julie, Muller, William J., Giguère, Vincent
Publicado no Nat Commun (2016)

Rb1 and Trp53 cooperate to suppress prostate cancer lineage plasticity, metastasis, and antiandrogen resistance

Por Ku, Sheng Yu, Rosario, Spencer, Wang, Yanqing, Mu, Ping, Seshadri, Mukund, Goodrich, Zachary W., Goodrich, Maxwell M., Labbé, David P., Gomez, Eduardo Cortes, Wang, Jianmin, Long, Henry W., Xu, Bo, Brown, Myles, Loda, Massimo, Sawyers, Charles L., Ellis, Leigh, Goodrich, David W.
Publicado no Science (2017)

Gene expression profiling of prostate tissue identifies chromatin regulation as a potential link between obesity and lethal prostate cancer

Por Ebot, Ericka M., Gerke, Travis, Labbé, David P., Sinnott, Jennifer A., Zadra, Giorgia, Rider, Jennifer R., Tyekucheva, Svitlana, Wilson, Kathryn M., Kelly, Rachel S., Shui, Irene M., Loda, Massimo, Kantoff, Philip W., Finn, Stephen, Vander Heiden, Matthew G., Brown, Myles, Giovannucci, Edward L., Mucci, Lorelei A.
Publicado no Cancer (2017)

TOP2A and EZH2 provide early detection of an aggressive prostate cancer subgroup

Por Labbé, David P., Sweeney, Christopher J., Brown, Myles, Galbo, Phillip, Rosario, Spencer, Wadosky, Kristine M., Ku, Sheng-Yu, Sjöström, Martin, Alshalalfa, Mohammed, Erho, Nicholas, Davicioni, Elai, Karnes, R. Jeffrey, Schaeffer, Edward M., Jenkins, Robert B., Den, Robert B., Ross, Ashley E., Bowden, Michaela, Huang, Ying, Gray, Kathryn P., Feng, Felix Y., Spratt, Daniel E., Goodrich, David W., Eng, Kevin H., Ellis, Leigh
Publicado no Clin Cancer Res (2017)

High-fat diet fuels prostate cancer progression by rewiring the metabolome and amplifying the MYC program

Por Labbé, David P., Zadra, Giorgia, Yang, Meng, Reyes, Jaime M., Lin, Charles Y., Cacciatore, Stefano, Ebot, Ericka M., Creech, Amanda L., Giunchi, Francesca, Fiorentino, Michelangelo, Elfandy, Habiba, Syamala, Sudeepa, Karoly, Edward D., Alshalalfa, Mohammed, Erho, Nicholas, Ross, Ashley, Schaeffer, Edward M., Gibb, Ewan A., Takhar, Mandeep, Den, Robert B., Lehrer, Jonathan, Karnes, R. Jeffrey, Freedland, Stephen J., Davicioni, Elai, Spratt, Daniel E., Ellis, Leigh, Jaffe, Jacob D., DʼAmico, Anthony V., Kantoff, Philip W., Bradner, James E., Mucci, Lorelei A., Chavarro, Jorge E., Loda, Massimo, Brown, Myles
Publicado no Nat Commun (2019)

EZH2 inhibition activates a dsRNA–STING–interferon stress axis that potentiates response to PD-1 checkpoint blockade in prostate cancer

Por Morel, Katherine L., Sheahan, Anjali V., Burkhart, Deborah L., Baca, Sylvan C., Boufaied, Nadia, Liu, Yin, Qiu, Xintao, Cañadas, Israel, Roehle, Kevin, Heckler, Max, Calagua, Carla, Ye, Huihui, Pantelidou, Constantia, Galbo, Phillip, Panja, Sukanya, Mitrofanova, Antonina, Wilkinson, Scott, Whitlock, Nichelle C., Trostel, Shana Y., Hamid, Anis A., Kibel, Adam S., Barbie, David A., Choudhury, Atish D., Pomerantz, Mark M., Sweeney, Christopher J., Long, Henry W., Einstein, David J., Shapiro, Geoffrey I., Dougan, Stephanie K., Sowalsky, Adam G., He, Housheng Hansen, Freedman, Matthew L., Balk, Steven P., Loda, Massimo, Labbé, David P., Olson, Brian M., Ellis, Leigh
Publicado no Nat Cancer (2021)