EZH2 inhibition activates a dsRNA–STING–interferon stress axis that potentiates response to PD-1 checkpoint blockade in prostate cancer

Prostate cancers are considered to be immunologically ‘cold’ tumors given the very few patients who respond to checkpoint inhibitor (CPI) therapy. Recently, enrichment of interferon-stimulated genes (ISGs) predicted a favorable response to CPI across various disease sites. The enhancer of zeste homo...

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Vydáno v:Nat Cancer
Hlavní autoři: Morel, Katherine L., Sheahan, Anjali V., Burkhart, Deborah L., Baca, Sylvan C., Boufaied, Nadia, Liu, Yin, Qiu, Xintao, Cañadas, Israel, Roehle, Kevin, Heckler, Max, Calagua, Carla, Ye, Huihui, Pantelidou, Constantia, Galbo, Phillip, Panja, Sukanya, Mitrofanova, Antonina, Wilkinson, Scott, Whitlock, Nichelle C., Trostel, Shana Y., Hamid, Anis A., Kibel, Adam S., Barbie, David A., Choudhury, Atish D., Pomerantz, Mark M., Sweeney, Christopher J., Long, Henry W., Einstein, David J., Shapiro, Geoffrey I., Dougan, Stephanie K., Sowalsky, Adam G., He, Housheng Hansen, Freedman, Matthew L., Balk, Steven P., Loda, Massimo, Labbé, David P., Olson, Brian M., Ellis, Leigh
Médium: Artigo
Jazyk:Inglês
Vydáno: 2021
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8061902/
https://ncbi.nlm.nih.gov/pubmed/33899001
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s43018-021-00185-w
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