Subtle variations in Pten dose determine cancer susceptibility

Cancer susceptibility has been attributed to at least one heterozygous genetic alteration in a tumor suppressor gene (TSG)1. It has been hypothesized that subtle variations in TSG expression can promote cancer development2,3. However, this hypothesis has not yet been definitively supported in vivo....

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Detalhes bibliográficos
Main Authors: Alimonti, Andrea, Carracedo, Arkaitz, Clohessy, John G, Trotman, Lloyd C, Nardella, Caterina, Egia, Ainara, Salmena, Leonardo, Sampieri, Katia, Haveman, William J, Brogi, Edi, Richardson, Andrea L, Zhang, Jiangwen, Pandolfi, Pier Paolo
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3118559/
https://ncbi.nlm.nih.gov/pubmed/20400965
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ng.556
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