Subtle variations in Pten dose determine cancer susceptibility

Cancer susceptibility has been attributed to at least one heterozygous genetic alteration in a tumor suppressor gene (TSG)1. It has been hypothesized that subtle variations in TSG expression can promote cancer development2,3. However, this hypothesis has not yet been definitively supported in vivo....

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Alimonti, Andrea, Carracedo, Arkaitz, Clohessy, John G, Trotman, Lloyd C, Nardella, Caterina, Egia, Ainara, Salmena, Leonardo, Sampieri, Katia, Haveman, William J, Brogi, Edi, Richardson, Andrea L, Zhang, Jiangwen, Pandolfi, Pier Paolo
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2010
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3118559/
https://ncbi.nlm.nih.gov/pubmed/20400965
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ng.556
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