A co-clinical approach identifies mechanisms and potential therapies for androgen deprivation resistance in prostate cancer

Here we report an integrated analysis that leverages data from treatment of genetic mouse models of prostate cancer along with clinical data from patients to elucidate new mechanisms of castration resistance. We show that castration counteracts tumor progression in a Pten-loss driven mouse model of...

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Detalhes bibliográficos
Main Authors: Lunardi, Andrea, Ala, Ugo, Epping, Mirjam T., Salmena, Leonardo, Clohessy, John G., Webster, Kaitlyn A., Wang, Guocan, Mazzucchelli, Roberta, Bianconi, Maristella, Stack, Edward C., Lis, Rosina, Patnaik, Akash, Cantley, Lewis C., Bubley, Glenn, Cordon-Cardo, Carlos, Gerald, William L., Montironi, Rodolfo, Signoretti, Sabina, Loda, Massimo, Nardella, Caterina, Pandolfi, Pier Paolo
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3787876/
https://ncbi.nlm.nih.gov/pubmed/23727860
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ng.2650
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