A co-clinical approach identifies mechanisms and potential therapies for androgen deprivation resistance in prostate cancer

Here we report an integrated analysis that leverages data from treatment of genetic mouse models of prostate cancer along with clinical data from patients to elucidate new mechanisms of castration resistance. We show that castration counteracts tumor progression in a Pten-loss driven mouse model of...

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Detaylı Bibliyografya
Asıl Yazarlar: Lunardi, Andrea, Ala, Ugo, Epping, Mirjam T., Salmena, Leonardo, Clohessy, John G., Webster, Kaitlyn A., Wang, Guocan, Mazzucchelli, Roberta, Bianconi, Maristella, Stack, Edward C., Lis, Rosina, Patnaik, Akash, Cantley, Lewis C., Bubley, Glenn, Cordon-Cardo, Carlos, Gerald, William L., Montironi, Rodolfo, Signoretti, Sabina, Loda, Massimo, Nardella, Caterina, Pandolfi, Pier Paolo
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2013
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3787876/
https://ncbi.nlm.nih.gov/pubmed/23727860
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ng.2650
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