Lrf suppresses prostate cancer through repression of a Sox9-dependent pathway for cellular senescence bypass and tumor invasion

Lrf has been previously described as a powerful proto-oncogene. Here we surprisingly demonstrate that Lrf plays a critical oncosuppressive role in the prostate. Prostate specific inactivation of Lrf leads to a dramatic acceleration of Pten-loss-driven prostate tumorigenesis through a bypass of Pten-...

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Detalhes bibliográficos
Main Authors: Wang, Guocan, Lunardi, Andrea, Zhang, Jiangwen, Chen, Zhenbang, Ala, Ugo, Webster, Kaitlyn A., Tay, Yvonne, Gonzalez-Billalabeitia, Enrique, Egia, Ainara, Shaffer, David R., Carver, Brett, Liu, Xue-Song, Taulli, Riccardo, Kuo, Winston Patrick, Nardella, Caterina, Signoretti, Sabina, Cordon-Cardo, Carlos, Gerald, William L., Pandolfi, Pier Paolo
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4036521/
https://ncbi.nlm.nih.gov/pubmed/23727861
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ng.2654
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