Closing escape routes: inhibition of IL-8 signaling enhances the anti-tumor efficacy of PI3K inhibitors

Por Juvekar, Ashish, Wulf, Gerburg M
Publicado em 2013

PROTEASOME INHIBITORS INDUCE APOPTOSIS OF PROSTATE CANCER CELLS BY INDUCING NUCLEAR TRANSLOCATION OF IκBα

Por Vu, Hai-Yen, Juvekar, Ashish, Ghosh, Chandra, Ramaswami, Sitharam, Le, Dung Hong, Vancurova, Ivana
Publicado em 2008

Gene-Specific Repression of Proinflammatory Cytokines in Stimulated Human Macrophages by Nuclear IκBα

Por Ghosh, Chandra C., Ramaswami, Sitharam, Juvekar, Ashish, Vu, Hai-Yen, Galdieri, Luciano, Davidson, Dennis, Vancurova, Ivana
Publicado em 2010

Inhibition of cytokine signaling by ruxolitinib and implications for COVID-19 treatment

Por Yeleswaram, Swamy, Smith, Paul, Burn, Timothy, Covington, Maryanne, Juvekar, Ashish, Li, Yanlong, Squier, Peg, Langmuir, Peter
Publicado no Clin Immunol (2020)

Glutathione biosynthesis is a metabolic vulnerability in PI3K/Akt-driven breast cancer

Por Lien, Evan C., Lyssiotis, Costas A., Juvekar, Ashish, Hu, Hai, Asara, John M., Cantley, Lewis C., Toker, Alex
Publicado no Nat Cell Biol (2016)

Loss of BRCA1 leads to an increase in epidermal growth factor receptor expression in mammary epithelial cells, and epidermal growth factor receptor inhibition prevents estrogen rec...

Por Burga, Laura N, Hu, Hai, Juvekar, Ashish, Tung, Nadine M, Troyan, Susan L, Hofstatter, Erin W, Wulf, Gerburg M
Publicado em 2011

Bortezomib induces nuclear translocation of IκBα resulting in gene specific suppression of NFκB-dependent transcription and induction of apoptosis in CTCL

Por Juvekar, Ashish, Manna, Subrata, Ramaswami, Sitharam, Chang, Tzu-Pei, Vu, Hai-Yen, Ghosh, Chandra C, Celiker, Mahmut Y, Vancurova, Ivana
Publicado em 2011

Phosphoinositide 3-Kinase regulates glycolysis through mobilization of Aldolase A from the actin cytoskeleton

Por Hu, Hai, Juvekar, Ashish, Lyssiotis, Costas, Albeck, John G, Tolan, Dean R, Asara, John M, Wulf, Gerburg M, Cantley, Lewis C
Publicado em 2014

Itacitinib (INCB039110), a JAK1 inhibitor, Reduces Cytokines Associated with Cytokine Release Syndrome Induced by CAR T-Cell Therapy

Por Huarte, Eduardo, O’Connor, Roddy S., Peel, Michael T., Nunez-Cruz, Selene, Leferovich, John, Juvekar, Ashish, Yang, Yan-ou, Truong, Lisa, Huang, Taisheng, Naim, Ahmad, Milone, Michael C., Smith, Paul A.
Publicado no Clin Cancer Res (2020)

Phosphoinositide 3-kinase inhibitors induce DNA damage through nucleoside depletion

Por Juvekar, Ashish, Hu, Hai, Yadegarynia, Sina, Lyssiotis, Costas A., Ullas, Soumya, Lien, Evan C., Bellinger, Gary, Son, Jaekyoung, Hok, Rosanna C., Seth, Pankaj, Daly, Michele B., Kim, Baek, Scully, Ralph, Asara, John M., Cantley, Lewis C., Wulf, Gerburg M.
Publicado no Proc Natl Acad Sci U S A (2016)

Combining a PI3K inhibitor with a PARP inhibitor provides an effective therapy for BRCA1-related breast cancer

Por Juvekar, Ashish, Burga, Laura N., Hu, Hai, Lunsford, Elaine P., Ibrahim, Yasir H., Balmañà, Judith, Rajendran, Anbazhagan, Papa, Antonella, Spencer, Katherine, Lyssiotis, Costas A., Nardella, Caterina, Pandolfi, Pier Paolo, Baselga, Jose, Scully, Ralph, Asara, John M., Cantley, Lewis C., Wulf, Gerburg M.
Publicado em 2012

Phosphoinositide 3-Kinase Regulates Glycolysis through Mobilization of Aldolase from the Actin cytoskeleton

Por Hu, Hai, Juvekar, Ashish, Lyssiotis, Costas A., Lien, Evan C., Albeck, John G., Oh, Doogie, Varma, Gopal, Hung, Yin Pun, Ullas, Soumya, Lauring, Josh, Seth, Pankaj, Lundquist, Mark R., Tolan, Dean R., Grant, Aaron K., Needleman, Daniel J., Asara, John M., Cantley, Lewis C., Wulf, Gerburg M.
Publicado no Cell (2016)