Closing escape routes: inhibition of IL-8 signaling enhances the anti-tumor efficacy of PI3K inhibitors

door Juvekar, Ashish, Wulf, Gerburg M
Gepubliceerd in 2013

PROTEASOME INHIBITORS INDUCE APOPTOSIS OF PROSTATE CANCER CELLS BY INDUCING NUCLEAR TRANSLOCATION OF IκBα

door Vu, Hai-Yen, Juvekar, Ashish, Ghosh, Chandra, Ramaswami, Sitharam, Le, Dung Hong, Vancurova, Ivana
Gepubliceerd in 2008

Gene-Specific Repression of Proinflammatory Cytokines in Stimulated Human Macrophages by Nuclear IκBα

door Ghosh, Chandra C., Ramaswami, Sitharam, Juvekar, Ashish, Vu, Hai-Yen, Galdieri, Luciano, Davidson, Dennis, Vancurova, Ivana
Gepubliceerd in 2010

Inhibition of cytokine signaling by ruxolitinib and implications for COVID-19 treatment

door Yeleswaram, Swamy, Smith, Paul, Burn, Timothy, Covington, Maryanne, Juvekar, Ashish, Li, Yanlong, Squier, Peg, Langmuir, Peter
Gepubliceerd in Clin Immunol (2020)

Glutathione biosynthesis is a metabolic vulnerability in PI3K/Akt-driven breast cancer

door Lien, Evan C., Lyssiotis, Costas A., Juvekar, Ashish, Hu, Hai, Asara, John M., Cantley, Lewis C., Toker, Alex
Gepubliceerd in Nat Cell Biol (2016)

Loss of BRCA1 leads to an increase in epidermal growth factor receptor expression in mammary epithelial cells, and epidermal growth factor receptor inhibition prevents estrogen rec...

door Burga, Laura N, Hu, Hai, Juvekar, Ashish, Tung, Nadine M, Troyan, Susan L, Hofstatter, Erin W, Wulf, Gerburg M
Gepubliceerd in 2011

Bortezomib induces nuclear translocation of IκBα resulting in gene specific suppression of NFκB-dependent transcription and induction of apoptosis in CTCL

door Juvekar, Ashish, Manna, Subrata, Ramaswami, Sitharam, Chang, Tzu-Pei, Vu, Hai-Yen, Ghosh, Chandra C, Celiker, Mahmut Y, Vancurova, Ivana
Gepubliceerd in 2011

Phosphoinositide 3-Kinase regulates glycolysis through mobilization of Aldolase A from the actin cytoskeleton

door Hu, Hai, Juvekar, Ashish, Lyssiotis, Costas, Albeck, John G, Tolan, Dean R, Asara, John M, Wulf, Gerburg M, Cantley, Lewis C
Gepubliceerd in 2014

Itacitinib (INCB039110), a JAK1 inhibitor, Reduces Cytokines Associated with Cytokine Release Syndrome Induced by CAR T-Cell Therapy

door Huarte, Eduardo, O’Connor, Roddy S., Peel, Michael T., Nunez-Cruz, Selene, Leferovich, John, Juvekar, Ashish, Yang, Yan-ou, Truong, Lisa, Huang, Taisheng, Naim, Ahmad, Milone, Michael C., Smith, Paul A.
Gepubliceerd in Clin Cancer Res (2020)

Phosphoinositide 3-kinase inhibitors induce DNA damage through nucleoside depletion

door Juvekar, Ashish, Hu, Hai, Yadegarynia, Sina, Lyssiotis, Costas A., Ullas, Soumya, Lien, Evan C., Bellinger, Gary, Son, Jaekyoung, Hok, Rosanna C., Seth, Pankaj, Daly, Michele B., Kim, Baek, Scully, Ralph, Asara, John M., Cantley, Lewis C., Wulf, Gerburg M.
Gepubliceerd in Proc Natl Acad Sci U S A (2016)

Combining a PI3K inhibitor with a PARP inhibitor provides an effective therapy for BRCA1-related breast cancer

door Juvekar, Ashish, Burga, Laura N., Hu, Hai, Lunsford, Elaine P., Ibrahim, Yasir H., Balmañà, Judith, Rajendran, Anbazhagan, Papa, Antonella, Spencer, Katherine, Lyssiotis, Costas A., Nardella, Caterina, Pandolfi, Pier Paolo, Baselga, Jose, Scully, Ralph, Asara, John M., Cantley, Lewis C., Wulf, Gerburg M.
Gepubliceerd in 2012

Phosphoinositide 3-Kinase Regulates Glycolysis through Mobilization of Aldolase from the Actin cytoskeleton

door Hu, Hai, Juvekar, Ashish, Lyssiotis, Costas A., Lien, Evan C., Albeck, John G., Oh, Doogie, Varma, Gopal, Hung, Yin Pun, Ullas, Soumya, Lauring, Josh, Seth, Pankaj, Lundquist, Mark R., Tolan, Dean R., Grant, Aaron K., Needleman, Daniel J., Asara, John M., Cantley, Lewis C., Wulf, Gerburg M.
Gepubliceerd in Cell (2016)