Phosphoinositide 3-Kinase Regulates Glycolysis through Mobilization of Aldolase from the Actin cytoskeleton

The Phosphoinositide 3-Kinase (PI3K) pathway regulates multiple steps in glucose metabolism but also cytoskeletal functions, such as cell movement and attachment. Here we show that PI3K directly coordinates glycolysis with cytoskeletal dynamics in an AKT-independent manner. Growth factors or insulin...

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Pubblicato in:Cell
Autori principali: Hu, Hai, Juvekar, Ashish, Lyssiotis, Costas A., Lien, Evan C., Albeck, John G., Oh, Doogie, Varma, Gopal, Hung, Yin Pun, Ullas, Soumya, Lauring, Josh, Seth, Pankaj, Lundquist, Mark R., Tolan, Dean R., Grant, Aaron K., Needleman, Daniel J., Asara, John M., Cantley, Lewis C., Wulf, Gerburg M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2016
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4898774/
https://ncbi.nlm.nih.gov/pubmed/26824656
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2015.12.042
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