Phosphoinositide 3-kinase inhibitors induce DNA damage through nucleoside depletion

We previously reported that combining a phosphoinositide 3-kinase (PI3K) inhibitor with a poly-ADP Rib polymerase (PARP)-inhibitor enhanced DNA damage and cell death in breast cancers that have genetic aberrations in BRCA1 and TP53. Here, we show that enhanced DNA damage induced by PI3K inhibitors i...

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Vydáno v:Proc Natl Acad Sci U S A
Hlavní autoři: Juvekar, Ashish, Hu, Hai, Yadegarynia, Sina, Lyssiotis, Costas A., Ullas, Soumya, Lien, Evan C., Bellinger, Gary, Son, Jaekyoung, Hok, Rosanna C., Seth, Pankaj, Daly, Michele B., Kim, Baek, Scully, Ralph, Asara, John M., Cantley, Lewis C., Wulf, Gerburg M.
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2016
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PNAS Plus
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4968752/
https://ncbi.nlm.nih.gov/pubmed/27402769
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1522223113
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