Phosphoinositide 3-kinase inhibitors induce DNA damage through nucleoside depletion

We previously reported that combining a phosphoinositide 3-kinase (PI3K) inhibitor with a poly-ADP Rib polymerase (PARP)-inhibitor enhanced DNA damage and cell death in breast cancers that have genetic aberrations in BRCA1 and TP53. Here, we show that enhanced DNA damage induced by PI3K inhibitors i...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Juvekar, Ashish, Hu, Hai, Yadegarynia, Sina, Lyssiotis, Costas A., Ullas, Soumya, Lien, Evan C., Bellinger, Gary, Son, Jaekyoung, Hok, Rosanna C., Seth, Pankaj, Daly, Michele B., Kim, Baek, Scully, Ralph, Asara, John M., Cantley, Lewis C., Wulf, Gerburg M.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2016
Assuntos:
PNAS Plus
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4968752/
https://ncbi.nlm.nih.gov/pubmed/27402769
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1522223113
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