Loss of BRCA1 leads to an increase in epidermal growth factor receptor expression in mammary epithelial cells, and epidermal growth factor receptor inhibition prevents estrogen receptor-negative cancers in BRCA1-mutant mice

INTRODUCTION: Women who carry a BRCA1 mutation typically develop "triple-negative" breast cancers (TNBC), defined by the absence of estrogen receptor (ER), progesterone receptor and Her2/neu. In contrast to ER-positive tumors, TNBCs frequently express high levels of epidermal growth factor...

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Autores principales: Burga, Laura N, Hu, Hai, Juvekar, Ashish, Tung, Nadine M, Troyan, Susan L, Hofstatter, Erin W, Wulf, Gerburg M
Formato: Artigo
Lenguaje:Inglês
Publicado: BioMed Central 2011
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3219192/
https://ncbi.nlm.nih.gov/pubmed/21396117
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/bcr2850
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