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PROTEASOME INHIBITORS INDUCE APOPTOSIS OF PROSTATE CANCER CELLS BY INDUCING NUCLEAR TRANSLOCATION OF IκBα

Proteasome inhibitors are known to suppress the proteasome-mediated degradation of IκBα in stimulated cells. This results in the cytoplasmic retention of NFκB and its reduced nuclear transcriptional activity. In this study, we show that in the metastatic prostate cancer cells, the proteasome inhibit...

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שמור ב:
מידע ביבליוגרפי
Main Authors: Vu, Hai-Yen, Juvekar, Ashish, Ghosh, Chandra, Ramaswami, Sitharam, Le, Dung Hong, Vancurova, Ivana
פורמט: Artigo
שפה:Inglês
יצא לאור: 2008
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC2574911/
https://ncbi.nlm.nih.gov/pubmed/18468507
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.abb.2008.04.026
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