PROTEASOME INHIBITORS INDUCE APOPTOSIS OF PROSTATE CANCER CELLS BY INDUCING NUCLEAR TRANSLOCATION OF IκBα

Proteasome inhibitors are known to suppress the proteasome-mediated degradation of IκBα in stimulated cells. This results in the cytoplasmic retention of NFκB and its reduced nuclear transcriptional activity. In this study, we show that in the metastatic prostate cancer cells, the proteasome inhibit...

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Hlavní autoři: Vu, Hai-Yen, Juvekar, Ashish, Ghosh, Chandra, Ramaswami, Sitharam, Le, Dung Hong, Vancurova, Ivana
Médium: Artigo
Jazyk:Inglês
Vydáno: 2008
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2574911/
https://ncbi.nlm.nih.gov/pubmed/18468507
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.abb.2008.04.026
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