Ubiquitination regulates PTEN nuclear import and tumor suppression

The PTEN tumor-suppressor is frequently affected in cancer, and inherited PTEN mutation causes cancer-susceptibility conditions such as Cowden Syndrome. PTEN acts as a plasma-membrane lipid-phosphatase antagonizing the PI-3-Kinase/AKT pathway. However, PTEN is also found in cell nuclei, but mechanis...

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Main Authors: Trotman, Lloyd C., Wang, Xinjiang, Alimonti, Andrea, Chen, Zhenbang, Teruya-Feldstein, Julie, Yang, Haijuan, Pavletich, Nikola P., Carver, Brett S., Cordon-Cardo, Carlos, Erdjument-Bromage, Hediye, Tempst, Paul, Chi, Sung-Gil, Kim, Hyo-Jong, Misteli, Tom, Jiang, Xuejun, Pandolfi, Pier Paolo
Format: Artigo
Sprog:Inglês
Udgivet: 2007
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1855245/
https://ncbi.nlm.nih.gov/pubmed/17218261
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2006.11.040
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