Genetic analysis of Pten and Tsc2 functional interactions in the mouse reveals asymmetrical haploinsufficiency in tumor suppression

The role of tumor suppressor haploinsufficiency in oncogenesis is still poorly understood. The PTEN and TSC2 tumor suppressors function to antagonize mTOR (mammalian target of rapamycin) activation by Akt; hence, compound heterozygous inactivation of Pten and Tsc2 in the mouse may in principle exace...

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Bibliographic Details
Main Authors: Ma, Li, Teruya-Feldstein, Julie, Behrendt, Nille, Chen, Zhenbang, Noda, Tetsuo, Hino, Okio, Cordon-Cardo, Carlos, Pandolfi, Pier Paolo
Format: Artigo
Language:Inglês
Published: Cold Spring Harbor Laboratory Press 2005
Subjects:
Research Papers
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1182340/
https://ncbi.nlm.nih.gov/pubmed/16027168
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1314405
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