Genetic analysis of Pten and Tsc2 functional interactions in the mouse reveals asymmetrical haploinsufficiency in tumor suppression

The role of tumor suppressor haploinsufficiency in oncogenesis is still poorly understood. The PTEN and TSC2 tumor suppressors function to antagonize mTOR (mammalian target of rapamycin) activation by Akt; hence, compound heterozygous inactivation of Pten and Tsc2 in the mouse may in principle exace...

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Detalhes bibliográficos
Main Authors: Ma, Li, Teruya-Feldstein, Julie, Behrendt, Nille, Chen, Zhenbang, Noda, Tetsuo, Hino, Okio, Cordon-Cardo, Carlos, Pandolfi, Pier Paolo
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2005
Assuntos:
Research Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1182340/
https://ncbi.nlm.nih.gov/pubmed/16027168
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1314405
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