Phosphorylation-dependent regulation cytosolic localization and oncogenic function of Skp2 by Akt/PKB

Skp2 is an F-box protein that forms the SCF complex with Skp1 and Cullin-1 to constitute an E3 ligase for ubiquitylation. Ubiquitylation and degradation of the p27 is critical for Skp2-mediated cell cycle entry, and overexpression and cytosolic accumulation of Skp2 have been clearly associated with...

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Bibliographic Details
Main Authors: Lin, Hui-Kuan, Wang, Guocan, Chen, Zhenbang, Teruya-Feldstein, Julie, Liu, Yan, Chan, Chia-Hsin, Yang, Wei-Lei, Erdjument-Bromage, Hediye, Nakayama, Keiichi I., Nimer, Stephen, Tempst, Paul, Pandolfi, Pier Paolo
Format: Artigo
Language:Inglês
Published: 2009
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2830812/
https://ncbi.nlm.nih.gov/pubmed/19270694
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncb1849
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