TBK1 Directly Engages Akt/PKB Survival Signaling to Support Oncogenic Transformation

The innate immune signaling kinase, TBK1, couples pathogen surveillance to induction of host defense mechanisms. Pathological activation of TBK1 in cancer can overcome programmed cell death cues, enabling cells to survive oncogenic stress. The mechanistic basis of TBK1 prosurvival signaling, however...

詳細記述

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書誌詳細
主要な著者: Ou, Yi-Hung, Torres, Michael, Ram, Rosalyn, Formstecher, Etienne, Roland, Christina, Cheng, Tzuling, Brekken, Rolf, Wurz, Ryan, Tasker, Andrew, Polverino, Tony, Tan, Seng-Lai, White, Michael A.
フォーマット: Artigo
言語:Inglês
出版事項: 2011
主題:
Article
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3073833/
https://ncbi.nlm.nih.gov/pubmed/21329883
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2011.01.019
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