TBK1 Directly Engages Akt/PKB Survival Signaling to Support Oncogenic Transformation

The innate immune signaling kinase, TBK1, couples pathogen surveillance to induction of host defense mechanisms. Pathological activation of TBK1 in cancer can overcome programmed cell death cues, enabling cells to survive oncogenic stress. The mechanistic basis of TBK1 prosurvival signaling, however...

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Bibliografiske detaljer
Main Authors: Ou, Yi-Hung, Torres, Michael, Ram, Rosalyn, Formstecher, Etienne, Roland, Christina, Cheng, Tzuling, Brekken, Rolf, Wurz, Ryan, Tasker, Andrew, Polverino, Tony, Tan, Seng-Lai, White, Michael A.
Format: Artigo
Sprog:Inglês
Udgivet: 2011
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3073833/
https://ncbi.nlm.nih.gov/pubmed/21329883
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2011.01.019
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