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Ubiquitin ligase Nedd4L targets activated Smad2/3 to limit TGF βsignaling
TGFβ induces phosphorylation of the transcription factors Smad2 and Smad3 at the C-terminus as well as at an interdomain linker region. TGFβ-induced linker phosphorylation marks the activated Smad proteins for proteasome-mediated destruction. Here we identify Nedd4L as the ubiquitin ligase responsib...
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| 主要な著者: | , , , , , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2009
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2796330/ https://ncbi.nlm.nih.gov/pubmed/19917253 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2009.09.043 |
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