Ubiquitin ligase Nedd4L targets activated Smad2/3 to limit TGF βsignaling

TGFβ induces phosphorylation of the transcription factors Smad2 and Smad3 at the C-terminus as well as at an interdomain linker region. TGFβ-induced linker phosphorylation marks the activated Smad proteins for proteasome-mediated destruction. Here we identify Nedd4L as the ubiquitin ligase responsib...

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Detalhes bibliográficos
Main Authors: Gao, Sheng, Alarcón, Claudio, Sapkota, Gopal, Rahman, Sadia, Chen, Pan-Yu, Goerner, Nina, Macias, Maria J., Erdjument-Bromage, Hediye, Tempst, Paul, Massagué, Joan
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2796330/
https://ncbi.nlm.nih.gov/pubmed/19917253
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2009.09.043
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