The TGFβ-induced phosphorylation and activation of p38 mitogen-activated protein kinase is mediated by MAP3K4 and MAP3K10 but not TAK1

Por Sapkota, Gopal P.
Publicado em 2013

The emerging roles of deubiquitylating enzymes (DUBs) in the TGFβ and BMP pathways

Por Herhaus, Lina, Sapkota, Gopal P.
Publicado no Cell Signal (2014)

Regulation of the transforming growth factor β pathway by reversible ubiquitylation

Por Al-Salihi, Mazin A., Herhaus, Lina, Sapkota, Gopal P.
Publicado em 2012

Unique players in the BMP pathway: Small C-terminal domain phosphatases dephosphorylate Smad1 to attenuate BMP signaling

Por Knockaert, Marie, Sapkota, Gopal, Alarcón, Claudio, Massagué, Joan, Brivanlou, Ali H.
Publicado em 2006

USP11 augments TGFβ signalling by deubiquitylating ALK5

Por Al-Salihi, Mazin A., Herhaus, Lina, Macartney, Thomas, Sapkota, Gopal P.
Publicado em 2012

OTUB1 enhances TGFβ signalling by inhibiting the ubiquitylation and degradation of active SMAD2/3

Por Herhaus, Lina, Al-Salihi, Mazin, Macartney, Thomas, Weidlich, Simone, Sapkota, Gopal P.
Publicado em 2013

Identification and characterization of four novel phosphorylation sites (Ser31, Ser325, Thr336 and Thr366) on LKB1/STK11, the protein kinase mutated in Peutz-Jeghers cancer syndrom...

Por Sapkota, Gopal P, Boudeau, Jérôme, Deak, Maria, Kieloch, Agnieszka, Morrice, Nick, Alessi, Dario R
Publicado em 2002

Rapid generation of endogenously driven transcriptional reporters in cells through CRISPR/Cas9

Por Rojas-Fernandez, Alejandro, Herhaus, Lina, Macartney, Thomas, Lachaud, Christophe, Hay, Ronald T., Sapkota, Gopal P.
Publicado no Sci Rep (2015)

An affinity-directed protein missile system for targeted proteolysis

Por Fulcher, Luke J., Macartney, Thomas, Bozatzi, Polyxeni, Hornberger, Annika, Rojas-Fernandez, Alejandro, Sapkota, Gopal P.
Publicado no Open Biol (2016)

Protein associated with SMAD1 (PAWS1/FAM83G) is a substrate for type I bone morphogenetic protein receptors and modulates bone morphogenetic protein signalling

Por Vogt, Janis, Dingwell, Kevin S., Herhaus, Lina, Gourlay, Robert, Macartney, Thomas, Campbell, David, Smith, James C., Sapkota, Gopal P.
Publicado em 2014

Casein kinase 2 (CK2) phosphorylates the deubiquitylase OTUB1 at Ser(16) to trigger its nuclear localization

Por Herhaus, Lina, Perez-Oliva, Ana B., Cozza, Giorgio, Gourlay, Robert, Weidlich, Simone, Campbell, David G., Pinna, Lorenzo A., Sapkota, Gopal P.
Publicado no Sci Signal (2015)

Identification of in vitro and in vivo phosphorylation sites in the catalytic subunit of the DNA-dependent protein kinase.

Por Douglas, Pauline, Sapkota, Gopal P, Morrice, Nick, Yu, Yaping, Goodarzi, Aaron A, Merkle, Dennis, Meek, Katheryn, Alessi, Dario R, Lees-Miller, Susan P
Publicado em 2002

Ionizing radiation induces ataxia telangiectasia mutated kinase (ATM)-mediated phosphorylation of LKB1/STK11 at Thr-366.

Por Sapkota, Gopal P, Deak, Maria, Kieloch, Agnieszka, Morrice, Nick, Goodarzi, Aaron A, Smythe, Carl, Shiloh, Yosef, Lees-Miller, Susan P, Alessi, Dario R
Publicado em 2002

Ubiquitin ligase Nedd4L targets activated Smad2/3 to limit TGF βsignaling

Por Gao, Sheng, Alarcón, Claudio, Sapkota, Gopal, Rahman, Sadia, Chen, Pan-Yu, Goerner, Nina, Macias, Maria J., Erdjument-Bromage, Hediye, Tempst, Paul, Massagué, Joan
Publicado em 2009

BI-D1870 is a specific inhibitor of the p90 RSK (ribosomal S6 kinase) isoforms in vitro and in vivo

Por Sapkota, Gopal P., Cummings, Lorna, Newell, Felicity S., Armstrong, Christopher, Bain, Jennifer, Frodin, Morten, Grauert, Matthias, Hoffmann, Matthias, Schnapp, Gisela, Steegmaier, Martin, Cohen, Philip, Alessi, Dario R.
Publicado em 2006

USP15 targets ALK3/BMPR1A for deubiquitylation to enhance bone morphogenetic protein signalling

Por Herhaus, Lina, Al-Salihi, Mazin A., Dingwell, Kevin S., Cummins, Timothy D., Wasmus, Lize, Vogt, Janis, Ewan, Richard, Bruce, David, Macartney, Thomas, Weidlich, Simone, Smith, James C., Sapkota, Gopal P.
Publicado em 2014

CDK8/9 drive Smad transcriptional action, turnover and YAP interactions in BMP and TGFβ pathways

Por Alarcón, Claudio, Zaromytidou, Alexia-Ileana, Xi, Qiaoran, Gao, Sheng, Yu, Jianzhong, Fujisawa, Sho, Barlas, Afsar, Miller, Alexandria N., Manova-Todorova, Katia, Macias, Maria J., Sapkota, Gopal, Pan, Duojia, Massagué, Joan
Publicado em 2009

Discovery of Type II Inhibitors of TGFβ-Activated Kinase 1 (TAK1) and Mitogen-Activated Protein Kinase Kinase Kinase Kinase 2 (MAP4K2)

Por Tan, Li, Nomanbhoy, Tyzoon, Gurbani, Deepak, Patricelli, Matthew, Hunter, John, Geng, Jiefei, Herhaus, Lina, Zhang, Jianming, Pauls, Eduardo, Ham, Youngjin, Choi, Hwan Geun, Xie, Ting, Deng, Xianming, Buhrlage, Sara J., Sim, Taebo, Cohen, Philip, Sapkota, Gopal, Westover, Kenneth D., Gray, Nathanael S.
Publicado no J Med Chem (2014)

Inactivation of TGFβ receptors in stem cells drives cutaneous squamous cell carcinoma

Por Cammareri, Patrizia, Rose, Aidan M., Vincent, David F., Wang, Jun, Nagano, Ai, Libertini, Silvana, Ridgway, Rachel A., Athineos, Dimitris, Coates, Philip J., McHugh, Angela, Pourreyron, Celine, Dayal, Jasbani H. S., Larsson, Jonas, Weidlich, Simone, Spender, Lindsay C., Sapkota, Gopal P., Purdie, Karin J., Proby, Charlotte M., Harwood, Catherine A., Leigh, Irene M., Clevers, Hans, Barker, Nick, Karlsson, Stefan, Pritchard, Catrin, Marais, Richard, Chelala, Claude, South, Andrew P., Sansom, Owen J., Inman, Gareth J.
Publicado no Nat Commun (2016)