Ionizing radiation induces ataxia telangiectasia mutated kinase (ATM)-mediated phosphorylation of LKB1/STK11 at Thr-366.

The serine/threonine protein kinase LKB1 functions as a tumour suppressor, and mutations in this enzyme lead to the inherited Peutz-Jeghers cancer syndrome. We previously found that LKB1 was phosphorylated at Thr-366 in vivo, a residue conserved in mammalian, Xenopus and Drosophila LKB1, located on...

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Detalhes bibliográficos
Main Authors: Sapkota, Gopal P, Deak, Maria, Kieloch, Agnieszka, Morrice, Nick, Goodarzi, Aaron A, Smythe, Carl, Shiloh, Yosef, Lees-Miller, Susan P, Alessi, Dario R
Formato: Artigo
Idioma:Inglês
Publicado em: 2002
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1223019/
https://ncbi.nlm.nih.gov/pubmed/12234250
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20021284
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