Expanding the ubiquitin code through post-translational modification

Por Herhaus, Lina, Dikic, Ivan
Publicado no EMBO Rep (2015)

The emerging roles of deubiquitylating enzymes (DUBs) in the TGFβ and BMP pathways

Por Herhaus, Lina, Sapkota, Gopal P.
Publicado no Cell Signal (2014)

Regulation of the transforming growth factor β pathway by reversible ubiquitylation

Por Al-Salihi, Mazin A., Herhaus, Lina, Sapkota, Gopal P.
Publicado em 2012

USP11 augments TGFβ signalling by deubiquitylating ALK5

Por Al-Salihi, Mazin A., Herhaus, Lina, Macartney, Thomas, Sapkota, Gopal P.
Publicado em 2012

OTUB1 enhances TGFβ signalling by inhibiting the ubiquitylation and degradation of active SMAD2/3

Por Herhaus, Lina, Al-Salihi, Mazin, Macartney, Thomas, Weidlich, Simone, Sapkota, Gopal P.
Publicado em 2013

Structural basis for the recognition and degradation of host TRIM proteins by Salmonella effector SopA

Por Fiskin, Evgenij, Bhogaraju, Sagar, Herhaus, Lina, Kalayil, Sissy, Hahn, Marcel, Dikic, Ivan
Publicado no Nat Commun (2017)

Rapid generation of endogenously driven transcriptional reporters in cells through CRISPR/Cas9

Por Rojas-Fernandez, Alejandro, Herhaus, Lina, Macartney, Thomas, Lachaud, Christophe, Hay, Ronald T., Sapkota, Gopal P.
Publicado no Sci Rep (2015)

Protein associated with SMAD1 (PAWS1/FAM83G) is a substrate for type I bone morphogenetic protein receptors and modulates bone morphogenetic protein signalling

Por Vogt, Janis, Dingwell, Kevin S., Herhaus, Lina, Gourlay, Robert, Macartney, Thomas, Campbell, David, Smith, James C., Sapkota, Gopal P.
Publicado em 2014

Casein kinase 2 (CK2) phosphorylates the deubiquitylase OTUB1 at Ser(16) to trigger its nuclear localization

Por Herhaus, Lina, Perez-Oliva, Ana B., Cozza, Giorgio, Gourlay, Robert, Weidlich, Simone, Campbell, David G., Pinna, Lorenzo A., Sapkota, Gopal P.
Publicado no Sci Signal (2015)

Phosphorylation of OPTN by TBK1 enhances its binding to Ub chains and promotes selective autophagy of damaged mitochondria

Por Richter, Benjamin, Sliter, Danielle A., Herhaus, Lina, Stolz, Alexandra, Wang, Chunxin, Beli, Petra, Zaffagnini, Gabriele, Wild, Philipp, Martens, Sascha, Wagner, Sebastian A., Youle, Richard J., Dikic, Ivan
Publicado no Proc Natl Acad Sci U S A (2016)

USP15 targets ALK3/BMPR1A for deubiquitylation to enhance bone morphogenetic protein signalling

Por Herhaus, Lina, Al-Salihi, Mazin A., Dingwell, Kevin S., Cummins, Timothy D., Wasmus, Lize, Vogt, Janis, Ewan, Richard, Bruce, David, Macartney, Thomas, Weidlich, Simone, Smith, James C., Sapkota, Gopal P.
Publicado em 2014

Discovery of Type II Inhibitors of TGFβ-Activated Kinase 1 (TAK1) and Mitogen-Activated Protein Kinase Kinase Kinase Kinase 2 (MAP4K2)

Por Tan, Li, Nomanbhoy, Tyzoon, Gurbani, Deepak, Patricelli, Matthew, Hunter, John, Geng, Jiefei, Herhaus, Lina, Zhang, Jianming, Pauls, Eduardo, Ham, Youngjin, Choi, Hwan Geun, Xie, Ting, Deng, Xianming, Buhrlage, Sara J., Sim, Taebo, Cohen, Philip, Sapkota, Gopal, Westover, Kenneth D., Gray, Nathanael S.
Publicado no J Med Chem (2014)