Phosphorylation of OPTN by TBK1 enhances its binding to Ub chains and promotes selective autophagy of damaged mitochondria

Selective autophagy of damaged mitochondria requires autophagy receptors optineurin (OPTN), NDP52 (CALCOCO2), TAX1BP1, and p62 (SQSTM1) linking ubiquitinated cargo to autophagic membranes. By using quantitative proteomics, we show that Tank-binding kinase 1 (TBK1) phosphorylates all four receptors o...

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Bibliografski detalji
Izdano u:Proc Natl Acad Sci U S A
Glavni autori: Richter, Benjamin, Sliter, Danielle A., Herhaus, Lina, Stolz, Alexandra, Wang, Chunxin, Beli, Petra, Zaffagnini, Gabriele, Wild, Philipp, Martens, Sascha, Wagner, Sebastian A., Youle, Richard J., Dikic, Ivan
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2016
Teme:
Biological Sciences
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4839414/
https://ncbi.nlm.nih.gov/pubmed/27035970
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1523926113
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