Phosphorylation of OPTN by TBK1 enhances its binding to Ub chains and promotes selective autophagy of damaged mitochondria

Selective autophagy of damaged mitochondria requires autophagy receptors optineurin (OPTN), NDP52 (CALCOCO2), TAX1BP1, and p62 (SQSTM1) linking ubiquitinated cargo to autophagic membranes. By using quantitative proteomics, we show that Tank-binding kinase 1 (TBK1) phosphorylates all four receptors o...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Richter, Benjamin, Sliter, Danielle A., Herhaus, Lina, Stolz, Alexandra, Wang, Chunxin, Beli, Petra, Zaffagnini, Gabriele, Wild, Philipp, Martens, Sascha, Wagner, Sebastian A., Youle, Richard J., Dikic, Ivan
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2016
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4839414/
https://ncbi.nlm.nih.gov/pubmed/27035970
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1523926113
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