Alpha-synuclein fibrils recruit TBK1 and OPTN to lysosomal damage sites and induce autophagy in microglial cells

Autophagic dysfunction and protein aggregation have been linked to several neurodegenerative disorders, but the exact mechanisms and causal connections are not clear and most previous work was done in neurons and not in microglial cells. Here, we report that exogenous fibrillary, but not monomeric,...

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Detaylı Bibliyografya
Yayımlandı:J Cell Sci
Asıl Yazarlar: Bussi, Claudio, Peralta Ramos, Javier M., Arroyo, Daniela S., Gallea, Jose I., Ronchi, Paolo, Kolovou, Androniki, Wang, Ji M., Florey, Oliver, Celej, Maria S., Schwab, Yannick, Ktistakis, Nicholas T., Iribarren, Pablo
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: The Company of Biologists Ltd 2018
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6518333/
https://ncbi.nlm.nih.gov/pubmed/30404831
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.226241
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