Alpha-synuclein fibrils recruit TBK1 and OPTN to lysosomal damage sites and induce autophagy in microglial cells

Autophagic dysfunction and protein aggregation have been linked to several neurodegenerative disorders, but the exact mechanisms and causal connections are not clear and most previous work was done in neurons and not in microglial cells. Here, we report that exogenous fibrillary, but not monomeric,...

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Bibliografiska uppgifter
I publikationen:J Cell Sci
Huvudupphovsmän: Bussi, Claudio, Peralta Ramos, Javier M., Arroyo, Daniela S., Gallea, Jose I., Ronchi, Paolo, Kolovou, Androniki, Wang, Ji M., Florey, Oliver, Celej, Maria S., Schwab, Yannick, Ktistakis, Nicholas T., Iribarren, Pablo
Materialtyp: Artigo
Språk:Inglês
Publicerad: The Company of Biologists Ltd 2018
Ämnen:
Research Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC6518333/
https://ncbi.nlm.nih.gov/pubmed/30404831
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.226241
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