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Alpha-synuclein fibrils recruit TBK1 and OPTN to lysosomal damage sites and induce autophagy in microglial cells

Autophagic dysfunction and protein aggregation have been linked to several neurodegenerative disorders, but the exact mechanisms and causal connections are not clear and most previous work was done in neurons and not in microglial cells. Here, we report that exogenous fibrillary, but not monomeric,...

詳細記述

保存先:
書誌詳細
出版年:J Cell Sci
主要な著者: Bussi, Claudio, Peralta Ramos, Javier M., Arroyo, Daniela S., Gallea, Jose I., Ronchi, Paolo, Kolovou, Androniki, Wang, Ji M., Florey, Oliver, Celej, Maria S., Schwab, Yannick, Ktistakis, Nicholas T., Iribarren, Pablo
フォーマット: Artigo
言語:Inglês
出版事項: The Company of Biologists Ltd 2018
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC6518333/
https://ncbi.nlm.nih.gov/pubmed/30404831
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.226241
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