The PINK1-PARKIN mitochondrial ubiquitylation pathway drives a program of TBK1 activation and recruitment of OPTN and NDP52 to promote mitophagy

Damaged mitochondria are detrimental to cellular homeostasis. One mechanism for removal of damaged mitochondria involves the PINK1-PARKIN pathway, which poly-ubiquitylates damaged mitochondria to promote mitophagy. We report that assembly of ubiquitin chains on mitochondria triggers the recruitment...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Mol Cell
Main Authors: Heo, Jin-Mi, Ordureau, Alban, Paulo, Joao A., Rinehart, Jesse, Harper, J. Wade
Format: Artigo
Jezik:Inglês
Izdano: 2015
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4592482/
https://ncbi.nlm.nih.gov/pubmed/26365381
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2015.08.016
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