PINK1-dependent recruitment of Parkin to mitochondria in mitophagy

Phosphatase and tensin homolog (PTEN)-induced putative kinase 1 (PINK1) and PARK2/Parkin mutations cause autosomal recessive forms of Parkinson's disease. Upon a loss of mitochondrial membrane potential (ΔΨ(m)) in human cells, cytosolic Parkin has been reported to be recruited to mitochondria,...

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Autori principali: Vives-Bauza, Cristofol, Zhou, Chun, Huang, Yong, Cui, Mei, de Vries, Rosa L.A., Kim, Jiho, May, Jessica, Tocilescu, Maja Aleksandra, Liu, Wencheng, Ko, Han Seok, Magrané, Jordi, Moore, Darren J., Dawson, Valina L., Grailhe, Regis, Dawson, Ted M., Li, Chenjian, Tieu, Kim, Przedborski, Serge
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2009
Soggetti:
Biological Sciences
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2806779/
https://ncbi.nlm.nih.gov/pubmed/19966284
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0911187107
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