Cytosolic cleaved PINK1 represses Parkin translocation to mitochondria and mitophagy

PINK1 is a mitochondrial kinase proposed to have a role in the pathogenesis of Parkinson's disease through the regulation of mitophagy. Here, we show that the PINK1 main cleavage product, PINK1(52,) after being generated inside mitochondria, can exit these organelles and localize to the cytosol...

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Detalles Bibliográficos
Publicado en:EMBO Rep
Autores principales: Fedorowicz, Maja A, de Vries-Schneider, Rosa L A, Rüb, Cornelia, Becker, Dorothea, Huang, Yong, Zhou, Chun, Alessi Wolken, Dana M, Voos, Wolfgang, Liu, Yuhui, Przedborski, Serge
Formato: Artigo
Lenguaje:Inglês
Publicado: BlackWell Publishing Ltd 2014
Materias:
Scientific Reports
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4303452/
https://ncbi.nlm.nih.gov/pubmed/24357652
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/embr.201337294
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