Cytosolic cleaved PINK1 represses Parkin translocation to mitochondria and mitophagy

PINK1 is a mitochondrial kinase proposed to have a role in the pathogenesis of Parkinson's disease through the regulation of mitophagy. Here, we show that the PINK1 main cleavage product, PINK1(52,) after being generated inside mitochondria, can exit these organelles and localize to the cytosol...

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發表在:EMBO Rep
Main Authors: Fedorowicz, Maja A, de Vries-Schneider, Rosa L A, Rüb, Cornelia, Becker, Dorothea, Huang, Yong, Zhou, Chun, Alessi Wolken, Dana M, Voos, Wolfgang, Liu, Yuhui, Przedborski, Serge
格式: Artigo
語言:Inglês
出版: BlackWell Publishing Ltd 2014
主題:
Scientific Reports
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4303452/
https://ncbi.nlm.nih.gov/pubmed/24357652
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/embr.201337294
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