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Cytosolic cleaved PINK1 represses Parkin translocation to mitochondria and mitophagy
PINK1 is a mitochondrial kinase proposed to have a role in the pathogenesis of Parkinson's disease through the regulation of mitophagy. Here, we show that the PINK1 main cleavage product, PINK1(52,) after being generated inside mitochondria, can exit these organelles and localize to the cytosol...
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| Veröffentlicht in: | EMBO Rep |
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| Hauptverfasser: | , , , , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
BlackWell Publishing Ltd
2014
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4303452/ https://ncbi.nlm.nih.gov/pubmed/24357652 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/embr.201337294 |
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