Cytosolic cleaved PINK1 represses Parkin translocation to mitochondria and mitophagy

PINK1 is a mitochondrial kinase proposed to have a role in the pathogenesis of Parkinson's disease through the regulation of mitophagy. Here, we show that the PINK1 main cleavage product, PINK1(52,) after being generated inside mitochondria, can exit these organelles and localize to the cytosol...

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Detalhes bibliográficos
Publicado no:EMBO Rep
Main Authors: Fedorowicz, Maja A, de Vries-Schneider, Rosa L A, Rüb, Cornelia, Becker, Dorothea, Huang, Yong, Zhou, Chun, Alessi Wolken, Dana M, Voos, Wolfgang, Liu, Yuhui, Przedborski, Serge
Formato: Artigo
Idioma:Inglês
Publicado em: BlackWell Publishing Ltd 2014
Assuntos:
Scientific Reports
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4303452/
https://ncbi.nlm.nih.gov/pubmed/24357652
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/embr.201337294
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