Superoxide drives progression of Parkin/PINK1-dependent mitophagy following translocation of Parkin to mitochondria

Reactive oxygen species (ROS) and mitophagy are profoundly implicated in the pathogenesis of neurodegenerative diseases, such as Parkinson’s disease (PD). Several studies have suggested that ROS are not involved in mitochondrial translocation of Parkin which primes mitochondria for autophagic elimin...

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Detalhes bibliográficos
Publicado no:Cell Death Dis
Main Authors: Xiao, Bin, Deng, Xiao, Lim, Grace G Y, Xie, Shaoping, Zhou, Zhi Dong, Lim, Kah-Leong, Tan, Eng-King
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2017
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5680585/
https://ncbi.nlm.nih.gov/pubmed/29022898
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2017.463
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