Superoxide drives progression of Parkin/PINK1-dependent mitophagy following translocation of Parkin to mitochondria

Reactive oxygen species (ROS) and mitophagy are profoundly implicated in the pathogenesis of neurodegenerative diseases, such as Parkinson’s disease (PD). Several studies have suggested that ROS are not involved in mitochondrial translocation of Parkin which primes mitochondria for autophagic elimin...

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Dettagli Bibliografici
Pubblicato in:Cell Death Dis
Autori principali: Xiao, Bin, Deng, Xiao, Lim, Grace G Y, Xie, Shaoping, Zhou, Zhi Dong, Lim, Kah-Leong, Tan, Eng-King
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2017
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Original Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5680585/
https://ncbi.nlm.nih.gov/pubmed/29022898
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2017.463
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