Superoxide drives progression of Parkin/PINK1-dependent mitophagy following translocation of Parkin to mitochondria

Reactive oxygen species (ROS) and mitophagy are profoundly implicated in the pathogenesis of neurodegenerative diseases, such as Parkinson’s disease (PD). Several studies have suggested that ROS are not involved in mitochondrial translocation of Parkin which primes mitochondria for autophagic elimin...

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Bibliografiska uppgifter
I publikationen:Cell Death Dis
Huvudupphovsmän: Xiao, Bin, Deng, Xiao, Lim, Grace G Y, Xie, Shaoping, Zhou, Zhi Dong, Lim, Kah-Leong, Tan, Eng-King
Materialtyp: Artigo
Språk:Inglês
Publicerad: Nature Publishing Group 2017
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Original Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5680585/
https://ncbi.nlm.nih.gov/pubmed/29022898
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2017.463
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