Cytosolic cleaved PINK1 represses Parkin translocation to mitochondria and mitophagy

PINK1 is a mitochondrial kinase proposed to have a role in the pathogenesis of Parkinson's disease through the regulation of mitophagy. Here, we show that the PINK1 main cleavage product, PINK1(52,) after being generated inside mitochondria, can exit these organelles and localize to the cytosol...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:EMBO Rep
Egile Nagusiak: Fedorowicz, Maja A, de Vries-Schneider, Rosa L A, Rüb, Cornelia, Becker, Dorothea, Huang, Yong, Zhou, Chun, Alessi Wolken, Dana M, Voos, Wolfgang, Liu, Yuhui, Przedborski, Serge
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: BlackWell Publishing Ltd 2014
Gaiak:
Scientific Reports
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC4303452/
https://ncbi.nlm.nih.gov/pubmed/24357652
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/embr.201337294
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