PINK1-dependent recruitment of Parkin to mitochondria in mitophagy

Phosphatase and tensin homolog (PTEN)-induced putative kinase 1 (PINK1) and PARK2/Parkin mutations cause autosomal recessive forms of Parkinson's disease. Upon a loss of mitochondrial membrane potential (ΔΨ(m)) in human cells, cytosolic Parkin has been reported to be recruited to mitochondria,...

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Main Authors: Vives-Bauza, Cristofol, Zhou, Chun, Huang, Yong, Cui, Mei, de Vries, Rosa L.A., Kim, Jiho, May, Jessica, Tocilescu, Maja Aleksandra, Liu, Wencheng, Ko, Han Seok, Magrané, Jordi, Moore, Darren J., Dawson, Valina L., Grailhe, Regis, Dawson, Ted M., Li, Chenjian, Tieu, Kim, Przedborski, Serge
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2009
Teme:
Biological Sciences
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2806779/
https://ncbi.nlm.nih.gov/pubmed/19966284
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0911187107
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