Llwytho...
RAB7A phosphorylation by TBK1 promotes mitophagy via the PINK-PARKIN pathway
Removal of damaged mitochondria is orchestrated by a pathway involving the PINK1 kinase and the PARKIN ubiquitin ligase. Ubiquitin chains assembled by PARKIN on the mitochondrial outer membrane recruit autophagy cargo receptors in complexes with TBK1 protein kinase. While TBK1 is known to phosphoryl...
Wedi'i Gadw mewn:
| Cyhoeddwyd yn: | Sci Adv |
|---|---|
| Prif Awduron: | , , , , , , |
| Fformat: | Artigo |
| Iaith: | Inglês |
| Cyhoeddwyd: |
American Association for the Advancement of Science
2018
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| Pynciau: | |
| Mynediad Ar-lein: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6314648/ https://ncbi.nlm.nih.gov/pubmed/30627666 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.aav0443 |
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