Endosomal Rab cycles regulate Parkin-mediated mitophagy

Damaged mitochondria are selectively eliminated by mitophagy. Parkin and PINK1, gene products mutated in familial Parkinson’s disease, play essential roles in mitophagy through ubiquitination of mitochondria. Cargo ubiquitination by E3 ubiquitin ligase Parkin is important to trigger selective autoph...

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Detalhes bibliográficos
Publicado no:eLife
Main Authors: Yamano, Koji, Wang, Chunxin, Sarraf, Shireen A, Münch, Christian, Kikuchi, Reika, Noda, Nobuo N, Hizukuri, Yohei, Kanemaki, Masato T, Harper, Wade, Tanaka, Keiji, Matsuda, Noriyuki, Youle, Richard J
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2018
Assuntos:
Cell Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5780041/
https://ncbi.nlm.nih.gov/pubmed/29360040
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.31326
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