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Mitochondrial Rab GAPs govern autophagosome biogenesis during mitophagy

Damaged mitochondria can be selectively eliminated by mitophagy. Although two gene products mutated in Parkinson’s disease, PINK1, and Parkin have been found to play a central role in triggering mitophagy in mammals, how the pre-autophagosomal isolation membrane selectively and accurately engulfs da...

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Библиографические подробности
Главные авторы: Yamano, Koji, Fogel, Adam I, Wang, Chunxin, van der Bliek, Alexander M, Youle, Richard J
Формат: Artigo
Язык:Inglês
Опубликовано: eLife Sciences Publications, Ltd 2014
Предметы:
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3930140/
https://ncbi.nlm.nih.gov/pubmed/24569479
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.01612
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