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Parkin recruitment to impaired mitochondria for nonselective ubiquitylation is facilitated by MITOL
PINK1 (PARK6) and PARKIN (PARK2) are causal genes of recessive familial Parkinson's disease. Parkin is a ubiquitin ligase E3 that conjugates ubiquitin to impaired mitochondrial proteins for organelle degradation. PINK1, a Ser/Thr kinase that accumulates only on impaired mitochondria, phosphoryl...
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| Publicado no: | J Biol Chem |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6664184/ https://ncbi.nlm.nih.gov/pubmed/31110043 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.006302 |
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