A Dimeric PINK1-containing Complex on Depolarized Mitochondria Stimulates Parkin Recruitment

Parkinsonism typified by sporadic Parkinson disease is a prevalent neurodegenerative disease. Mutations in PINK1 (PTEN-induced putative kinase 1), a mitochondrial Ser/Thr protein kinase, or PARKIN, a ubiquitin-protein ligase, cause familial parkinsonism. The accumulation and autophosphorylation of P...

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Bibliographic Details
Main Authors:	Okatsu, Kei, Uno, Midori, Koyano, Fumika, Go, Etsu, Kimura, Mayumi, Oka, Toshihiko, Tanaka, Keiji, Matsuda, Noriyuki
Format:	Artigo
Language:	Inglês
Published:	American Society for Biochemistry and Molecular Biology 2013
Subjects:	Protein Synthesis and Degradation
Online Access:	https://ncbi.nlm.nih.gov/pmc/articles/PMC3868751/ https://ncbi.nlm.nih.gov/pubmed/24189060 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.509653
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A Dimeric PINK1-containing Complex on Depolarized Mitochondria Stimulates Parkin Recruitment

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