Unconventional PINK1 localization to the outer membrane of depolarized mitochondria drives Parkin recruitment

Dysfunction of PTEN-induced putative kinase 1 (PINK1), a Ser/Thr kinase with an N-terminal mitochondrial-targeting sequence (MTS), causes familial recessive parkinsonism. Reduction of the mitochondrial membrane potential limits MTS-mediated matrix import and promotes PINK1 accumulation on the outer...

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Bibliografische gegevens
Gepubliceerd in:J Cell Sci
Hoofdauteurs: Okatsu, Kei, Kimura, Mayumi, Oka, Toshihiko, Tanaka, Keiji, Matsuda, Noriyuki
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: The Company of Biologists 2015
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Research Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4342580/
https://ncbi.nlm.nih.gov/pubmed/25609704
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.161000
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