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Unconventional PINK1 localization to the outer membrane of depolarized mitochondria drives Parkin recruitment
Dysfunction of PTEN-induced putative kinase 1 (PINK1), a Ser/Thr kinase with an N-terminal mitochondrial-targeting sequence (MTS), causes familial recessive parkinsonism. Reduction of the mitochondrial membrane potential limits MTS-mediated matrix import and promotes PINK1 accumulation on the outer...
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| Publié dans: | J Cell Sci |
|---|---|
| Auteurs principaux: | , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
The Company of Biologists
2015
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4342580/ https://ncbi.nlm.nih.gov/pubmed/25609704 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.161000 |
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