PINK1 autophosphorylation upon membrane potential dissipation is essential for Parkin recruitment to damaged mitochondria

Dysfunction of PINK1, a mitochondrial Ser/Thr kinase, causes familial Parkinson's disease (PD). Recent studies have revealed that PINK1 is rapidly degraded in healthy mitochondria but accumulates on the membrane potential (ΔΨm)-deficient mitochondria, where it recruits another familial PD gene...

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Detalhes bibliográficos
Main Authors: Okatsu, Kei, Oka, Toshihiko, Iguchi, Masahiro, Imamura, Kenji, Kosako, Hidetaka, Tani, Naoki, Kimura, Mayumi, Go, Etsu, Koyano, Fumika, Funayama, Manabu, Shiba-Fukushima, Kahori, Sato, Shigeto, Shimizu, Hideaki, Fukunaga, Yuko, Taniguchi, Hisaaki, Komatsu, Masaaki, Hattori, Nobutaka, Mihara, Katsuyoshi, Tanaka, Keiji, Matsuda, Noriyuki
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Pub. Group 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3432468/
https://ncbi.nlm.nih.gov/pubmed/22910362
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms2016
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