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A Dimeric PINK1-containing Complex on Depolarized Mitochondria Stimulates Parkin Recruitment
Parkinsonism typified by sporadic Parkinson disease is a prevalent neurodegenerative disease. Mutations in PINK1 (PTEN-induced putative kinase 1), a mitochondrial Ser/Thr protein kinase, or PARKIN, a ubiquitin-protein ligase, cause familial parkinsonism. The accumulation and autophosphorylation of P...
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| Hauptverfasser: | , , , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
American Society for Biochemistry and Molecular Biology
2013
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3868751/ https://ncbi.nlm.nih.gov/pubmed/24189060 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.509653 |
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