A Dimeric PINK1-containing Complex on Depolarized Mitochondria Stimulates Parkin Recruitment

Parkinsonism typified by sporadic Parkinson disease is a prevalent neurodegenerative disease. Mutations in PINK1 (PTEN-induced putative kinase 1), a mitochondrial Ser/Thr protein kinase, or PARKIN, a ubiquitin-protein ligase, cause familial parkinsonism. The accumulation and autophosphorylation of P...

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Autores principales: Okatsu, Kei, Uno, Midori, Koyano, Fumika, Go, Etsu, Kimura, Mayumi, Oka, Toshihiko, Tanaka, Keiji, Matsuda, Noriyuki
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2013
Materias:
Protein Synthesis and Degradation
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3868751/
https://ncbi.nlm.nih.gov/pubmed/24189060
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.509653
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