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Phosphorylated ubiquitin chain is the genuine Parkin receptor
PINK1 selectively recruits Parkin to depolarized mitochondria for quarantine and removal of damaged mitochondria via ubiquitylation. Dysfunction of this process predisposes development of familial recessive Parkinson’s disease. Although various models for the recruitment process have been proposed,...
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| Publicado no: | J Cell Biol |
|---|---|
| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The Rockefeller University Press
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4395490/ https://ncbi.nlm.nih.gov/pubmed/25847540 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201410050 |
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