Phosphorylated ubiquitin chain is the genuine Parkin receptor

PINK1 selectively recruits Parkin to depolarized mitochondria for quarantine and removal of damaged mitochondria via ubiquitylation. Dysfunction of this process predisposes development of familial recessive Parkinson’s disease. Although various models for the recruitment process have been proposed,...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:J Cell Biol
Prif Awduron: Okatsu, Kei, Koyano, Fumika, Kimura, Mayumi, Kosako, Hidetaka, Saeki, Yasushi, Tanaka, Keiji, Matsuda, Noriyuki
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: The Rockefeller University Press 2015
Pynciau:
Research Articles
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4395490/
https://ncbi.nlm.nih.gov/pubmed/25847540
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201410050
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