Phosphorylated ubiquitin chain is the genuine Parkin receptor

PINK1 selectively recruits Parkin to depolarized mitochondria for quarantine and removal of damaged mitochondria via ubiquitylation. Dysfunction of this process predisposes development of familial recessive Parkinson’s disease. Although various models for the recruitment process have been proposed,...

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Vydáno v:J Cell Biol
Hlavní autoři: Okatsu, Kei, Koyano, Fumika, Kimura, Mayumi, Kosako, Hidetaka, Saeki, Yasushi, Tanaka, Keiji, Matsuda, Noriyuki
Médium: Artigo
Jazyk:Inglês
Vydáno: The Rockefeller University Press 2015
Témata:
Research Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4395490/
https://ncbi.nlm.nih.gov/pubmed/25847540
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201410050
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