Phosphorylated ubiquitin chain is the genuine Parkin receptor

PINK1 selectively recruits Parkin to depolarized mitochondria for quarantine and removal of damaged mitochondria via ubiquitylation. Dysfunction of this process predisposes development of familial recessive Parkinson’s disease. Although various models for the recruitment process have been proposed,...

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Publicat a:J Cell Biol
Autors principals: Okatsu, Kei, Koyano, Fumika, Kimura, Mayumi, Kosako, Hidetaka, Saeki, Yasushi, Tanaka, Keiji, Matsuda, Noriyuki
Format: Artigo
Idioma:Inglês
Publicat: The Rockefeller University Press 2015
Matèries:
Research Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4395490/
https://ncbi.nlm.nih.gov/pubmed/25847540
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201410050
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